The grade, but not the incidence, of infiltrating cell histiocytosis of the mesenteric lymph nodes was increased in all treated groups after 24 months of treatment. In addition, data were available from other surveys on the concentrations in five major food groups. Reich, A,G., Waylett, D.K., van der Reit, E., Doyl, E., Douglass, J.S., Eickhoff, J.C. & Heimbach, J.T. No significant changes in these functions were observed in Kupffer cells isolated from treated Sprague-Dawley rats (Hoglen et al., 1998). In phase II of the study, groups of eight female Fischer 344 were fed diets containing P15 mineral oil at 0%, 0.02% or 2.0% and Sprague-Dawley rats were fed diets containing 0%, 1.0% or 2.0% for 120 days, followed by a 30-day recovery period. These species undergo β-fission to give lighter carbocations and alkenes, and also undergo hydrogen-transfer reactions with alkane molecules so as to propagate the catalysis as a linear chain reaction. Histological analysis revealed quantifiable amounts of hydrocarbon in the livers of treated animals; the hepatic concentrations of mineral hydrocarbon in animals at the highest dose reached nearly a maximum within 3 months (900 µg/g tissue) and increased slowly up to 24 months of treatment. A higher threshold number of ED2-positive Kupffer cells was seen in control Sprague-Dawley rats than in control Fischer 344 rats. 1996). Based on the results of the study the Panel concluded that no carcinogenic effect was observed in F344 rats tested with MVMO and HVMO. Journal of the European Academy of Dermatology and Venereology. No deaths occurred during the study. The former category includes white mineral oils (various viscosities), paraffin waxes (low melting-point), microcrystalline wax (high melting-point) and petroleum jelly, which are used in coating and packaging materials, during bakery and confectionery manufacture and in grain and seed dust control. Learn about our remote access options. They are applied as hydrodynamic lubricants and as carriers of additives promoting boundary or solid-film lubrication. While the incidence of this lesion was not increased over that in controls in males allowed to recover for 12 months, data from the 12-month sacrifice were not available to assess the significance of this observation. Submitted to WHO by CONCAWE, Brussels, Belgium. The pigmented macrophages observed with P70(H) oil at 2% in the diet (equivalent to 2000 mg/kg bw per day) in the 90-day study reviewed at the forty-fourth meeting, on which the ADI was based, were not observed after 24 months’ intake at doses up to 1200 mg/kg bw per day. Use the link below to share a full-text version of this article with your friends and colleagues. Mineral oils are produced from refined hydrocarbons obtained from crude oil by distillation. R. Parallel studies were conducted to assess the long-term toxic and carcinogenic effects of P70(H) mineral oil (medium and low viscosity, class I) and P100(H) mineral oil (high viscosity) in male and female Fischer 344 rats after 2 years’ administration in the diet. The process is continuous, the whole catalyst charge passing through the reactor and coke burner every ten minutes or so. The extent of accumulation of mineral hydrocarbons in tissues ranged from 0.01% to nearly 3%; the tissues with the greatest accumulation of hydrocarbon were not those with the greatest likelihood of histopathological alterations. By this reaction a metal soap is formed, which is chemically bonded to the surface and as such exhibits boundary lubrication properties. (undated) Pilot pharmacokinetic studies on mineral hydrocarbons (MHC). Body weights and food consumption were measured throughout the study. 11 pp. White Mineral Oil USP/NF. This exposure is below the established group ADI. Mean body weights were not affected by consumption of diets containing low melting-point paraffin wax. At scheduled necropsy, the weights of the brain, heart, kidney, liver, mesenteric lymph nodes and spleen from all the animals were recorded. © In phase I, groups of eight female Fischer 344 rats were fed diets containing P15 mineral oil at 0%, 0.02% or 2.0% and groups of eight female Sprague-Dawley rats were fed diets containing 0%, 1.0% or 2.0% for 90 days. Histological analysis revealed quantifiable amounts of hydrocarbon in the livers of treated animals; the hepatic concentrations of mineral hydrocarbon in animals at the highest dose reached nearly a maximum within 3 months and increased slowly up to 24 months of treatment. Additives providing boundary lubrication properties are fatty acids, fatty esters, fatty oils, or soap. This was not considered treatment-related, however, as the incidence in treated groups was not dose-related and was within the range for other control female Fischer 344 rats. The studies were conducted in compliance with US Food and Drug Administration Good Laboratory Practice Regulations and the OECD Principles of Good Laboratory Practice. With this method, the gross mean intake of 0.47 mg/kg bw per day based on maximum use levels was reduced to 0.09 mg/kg bw per day (Table 9). The use of white mineral oil for grain dust control is common in the United States and has been reported in France as a minor application. Aside from the earlier onset and increased severity of reticuloendothelial-cell hyperplasia of the mesenteric lymph nodes and the greater increase in the weights of mesenteric lymph nodes in response to dietary administration of P70(H), there was little difference in response to the two oils. The weights of the kidney, heart and brain were not affected by treatment. MOHs are present in several food-contact materials, including food packaging materials made from recycled paper and board, and printing inks applied to paper and board. & Halladay, J.S. 1996). Microcrystalline wax is used primarily in wax-laminated flexible packaging (23%), curtain coating for corrugated cartons (22%) and flexible packaging with wax-coated substrates (22%). In addition, sections of the liver were evaluated by electron microscopy to assess Kupffer cell activation and the nature of the accumulated lipid material. The glass melts during the forming operation thereby forming a protecting liquid film between the hot workpiece and the cooler tool surface and lowering friction owing to the low shear strength of the film. The oils also complied with the requirements of the Japanese food additive standards and the Japanese pharmacopoeia. Incubation of liver microsomes with 84 µmol/l heptadecane resulted in the production of three metabolites: the corresponding alcohol and acid, heptadecanol and heptadecanoic acid. The weights of mesenteric lymph nodes after the recovery period were not provided. (1998) Alteration of Kupffer cell function and morphology by low melt point paraffin wax in female Fischer-344 but not Sprague-Dawley rats. h���o�6��>��D��@a��g�����ښ#@�[���~w'���N�b@.����ڂqa���P�׊q�t4���1LXjmY��8&��ə���7o���U��j���g�ß%{�Mn���z�Y��%t�O������f݂��y���r�q�9�K]5����ht�����,w�u�p��ݼZ����||[�ˇ�i-�Iՙ. Mineral oil, suitable for preparation of Nujol mulls for infrared spectroscopy, light oil, 330760: Mineral oil, heavy, M1180: Mineral oil, meets USP testing specifications, 69794: Mineral oil, BioUltra, for molecular biology, M8662: Mineral oil, PCR Reagent, PX0045: Mineral oil, white, Sorry we cannot compare more than 4 products at a time. In the alveolar spaces, macrophages accumulate and phagocytose the emulsified oil. In the livers of Sprague-Dawley rats, the maximum amount of radioactivity (2%) occurred at 8 h and decreased thereafter to reach 0.1% by 96 h. By contrast, the maximum amount of radioactivity in the livers of Fischer 344 rats (4%) was not reached until 24 h, and 3% of the administered radioactivity was still present at 96 h. The authors concluded that Sprague-Dawley rats can efficiently metabolize and excrete 14C-containing compounds, whereas the inability of Fischer 344 rats to clear these compounds from the liver probably resulted in deposition and possible retention. These results confirm the observation in the previous studies, that Fischer 344 and Sprague-Dawley rats differ in terms of the amount of mineral hydrocarbon retained in liver and mesenteric lymph nodes (Sipes & Halladay, 2001b). Kupffer cells were isolated from the liver and assayed for production of superoxide anion, nitrite ion, tumour necrosis factor-alpha (TNF-alpha and leukotriene B4, phagocytic activity and morphology. With the exception of natural fats, few of the substances mentioned above fulfill all the requirements of a metal forming lubricant. Animals on the C80 wax diets had increased food intake during weeks 1–4 of both studies. Oil viscosity is the parameter that plays an important role in lubrication. They are used in metal rolling applications. Ingunn Holen, Michelle A. Lawson, in Bone Cancer (Second Edition), 2015.

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